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Laboratory of Peptide & Amyloid Research
Research interest
Our research interest is centered mainly on synthetic organic chemistry and chemical biology. The first direction of research includes the development of newer methodologies for the synthesis of peptides, azapeptides, sulfonamides, hydroxamic acids, urea based peptides etc. and also the development of newer coupling reagents for peptide synthesis and other organic reactions.
We have developed some Oxyma based recyclable coupling reagents. Selected examples:
We are also investigating the supramolecular self-assembly of small peptides
In parallel, we are also working on the disruption of amyloid aggregation. Amyloidoses, e.g., Alzheimer’s disease, diabetes type II, Parkinson’s disease, etc., are major age related problems at present. Knowledge on the evolution, propagation, and remedy for these diseases are limited. We are working on strategies development for Amyloid disruption. Side by side, works on the elucidation of the pathway of amyloid formation is also in progress.
β-Sheet Breaker Hybrid peptide (BSBHP) against Alzheimer's disease:
Mechanistic pathway : β-Sheet Breaker Hybrid peptide (BSBHP) disrupts amyloid aggregates
Ashim Paul, Krishna Chaitanya Nadimpally, Tanmay Mondal, Kishore Thalluri, and Bhubaneswar Mandal*, "Inhibition of Alzheimer’s Amyloid-β Peptide Aggregation and its Disruption by a Conformationally Restricted α/β Hybrid Peptide" Chemical Communications, 2015, 51, 2245-2248.
β- Breaker Di-Peptide (BBDP) against Alzheimer's disease:
Krishna Chaitanya Nadimpally, Ashim Paul and Bhubaneswar Mandal*, "Reversal of aggregation using β breaker dipeptide containing peptides: Application to Aβ(1-40) self assembly and its inhibition" ACS Chemical Neuroscience, 2014, 5 (5), 400–408. DOI: 10.1021/cn500064z.
We have synthesized four 38 membered peptide, Ab38 and three of its proline mutants and studied their aggregation behavior.
Krishna Chaitanya Nadimpally, Ashim Paul, Abhijit Saha, Bhubaneswar Mandal*, International Journal of Peptide Research and Therapeutics, 2013,19, 365-371.
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